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Mass directed auto purification system (preparative LC-MS)


The Waters Auto Purification HPLC/MS system (preparative LC-MS) provides users with the flexibility of using automated high-throughput runs for selective mass-directed fractionation. The configuration enables easy scale-up from:

  • analytical chromatography (micrograms)
  • semi-preparative chromatography (milligrams)
  • preparative chromatography (gram quantities)

In addition, a collection of columns (variety of sizes and chemistries) is available. The machine automates the collection of fractions detected by MS and or UV-VIS, tracks samples and fractions, and then presents the data in an easy-to-view format. The software can trigger collection using a variety of detector signals including:

  • PDA (UV/Visible)
  • Evaporative Light Scattering (ELSD)
  • MS
  • analog detectors


This system can be used for fast and mass directed purification of natural products extracts and new molecular entities important to food, pharmaceutical, agrichemical and other industries:

  • Primary metabolites
  • Secondary metabolites: phytonutrients and a broad range of other secondary metabolites 
  • Oligosaccharides
  • (Bio-active) peptides

Complementary Techniques

  • Grace Reveleris Flash system (designed to collect fractions of crude mixtures, using evaporative light scattering (ELSD) and UV detection)
  • MALDI-TOF MS (for further analysis of the isolated fractions)

Last edited by Oscar de Vos on 2020-10-08

Our expert(s)
Mark Sanders
Henk Schols
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Department of Agrotechnology and Food Sciences
Shared Research Facilities


Food Chemistry

To explore the potential of nature to improve the quality of life.

This Shared Research Facilities equipment database offers researchers from universities, research institutes and companies, including start-ups, the opportunity to find research equipment with their relevant expert and to use it, generally on a pay-per-use basis. The equipment is available at different locations at Wageningen Campus or other (company) locations. If you want to share your own research devices or if you need more information, please contact us.